Microbial production of nucleic acid-related substances

Identification of Low-Molecular-Weight Nucleic Acid-Related Substances Secreted by Streptomyces aureofaciens.

Streptomyces aureofaciens growth in chemically defined medium is actively associated with the secretion of low-molecular-weight nucleic acid-related substances and is linked to low availability of phosphate. Thirteen pure compounds were isolated, of which seven were identified.

Antagonists of nucleic acid derivatives. II. Reversal studies with substances structurally related to thymine.

One of the major problems of antimetabolite studies is the evaluation of the rale of “secondary reversing agents” (1). In a system in which there exists a competitive relationship between a metabolite and its antimetabolite, the effect of a secondary reversing agent is to increase the ratio of antimetabolite to metabolite required to produce a given inhibition; the secondary reversing agent can...

Microbial Propionic Acid Production

Propionic acid (propionate) is a commercially valuable carboxylic acid produced through microbial fermentation. Propionic acid is mainly used in the food industry but has recently found applications in the cosmetic, plastics and pharmaceutical industries. Propionate can be produced via various metabolic pathways, which can be classified into three major groups: fermentative pathways, biosynthet...

Part 1% Nucleic Acids the Structure of the Nucleic Acids and Related Substances

The Structure of Cyameluric Acid, Hydromelonic Acid and Related Substances.

Over a century ago, in 1835, Leopold Gmelin' prepared the substance tripotassium hydromelonate by heating potassium ferrocyanide with sulfur; he also made other salts of hydromelonic acid, and carried out analyses, which, however, were not sufficiently accurate to lead to correct formulas. He recognized the similarity of the substances to the group of nitrogen compounds discovered and named by ...